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butabarbital will lessen the extent or outcome of sulfamethoxazole by influencing hepatic enzyme CYP2C9/10 metabolism. Minor/Importance Unknown.butabarbital will minimize the level or effect of fosphenytoin by influencing hepatic enzyme CYP2C9/10 metabolism. Use Caution/Keep an eye on.butabarbital will reduce the extent or influence of ritonavir by